The Clonotypic T Cell Receptor Is a Source of Tumor‐associated Antigens in Cutaneous T Cell Lymphoma
Identifieur interne : 003499 ( Main/Exploration ); précédent : 003498; suivant : 003500The Clonotypic T Cell Receptor Is a Source of Tumor‐associated Antigens in Cutaneous T Cell Lymphoma
Auteurs : Carole L. Berger [États-Unis] ; Jack Longley [États-Unis] ; Douglas Hanlon [États-Unis] ; Michael Girardi [États-Unis] ; Richard Edelson [États-Unis]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2001-09.
Abstract
Abstract: To develop cancer vaccines for the treatment of cutaneous T cell lymphoma (CTCL), immunogenic peptides were identified by two approaches. First, through the use of “reverse immunology” the peptide sequence of the idiotypic region of the β chain of the T cell receptor (TCR) was determined and a series of overlapping peptides synthesized and tested for CD8 T cell recognition. In two patients, the idiotypic CDR3 region provided immunogenic epitopes that were recognized in a class I‐restricted fashion by autologous CD8 T cell lines. In a second strategy, peptides were isolated directly from class I MHC molecules on the CTCL surface and sequenced. A peptide with partial homology to sequences contained in the conserved variable portion of the clonotypic TCR β chain was recognized as immunogenic by autologous CD8 T cells. Therefore, both approaches demonstrated that the clonotypic TCR in CTCL is a source of immunogenic tumor epitopes. To confirm that recognition of TCR‐derived sequences provides immunoprotection against tumor growth, a murine model of T cell lymphoma was studied. The immunogenicity of a thymoma, which lacks cell surface TCR expression, was enhanced by transfection of the β chain of the TCR. The studies reviewed in this paper demonstrate that the TCR can serve as one source for immunogenic tumor peptides in T cell lymphoma in vitro and in vivo. Presentation of TCR epitopes on dendritic cells that express high levels of MHC, costimulatory, and adhesion molecules may provide an effective means for immunization against T cell malignancy.
Url:
DOI: 10.1111/j.1749-6632.2001.tb03715.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001B52
- to stream Istex, to step Curation: 001B52
- to stream Istex, to step Checkpoint: 000E21
- to stream Main, to step Merge: 003537
- to stream Main, to step Curation: 003499
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Clonotypic T Cell Receptor Is a Source of Tumor‐associated Antigens in Cutaneous T Cell Lymphoma</title><author><name sortKey="Berger, Carole L" sort="Berger, Carole L" uniqKey="Berger C" first="Carole L." last="Berger">Carole L. Berger</name></author><author><name sortKey="Longley, Jack" sort="Longley, Jack" uniqKey="Longley J" first="Jack" last="Longley">Jack Longley</name></author><author><name sortKey="Hanlon, Douglas" sort="Hanlon, Douglas" uniqKey="Hanlon D" first="Douglas" last="Hanlon">Douglas Hanlon</name></author><author><name sortKey="Girardi, Michael" sort="Girardi, Michael" uniqKey="Girardi M" first="Michael" last="Girardi">Michael Girardi</name></author><author><name sortKey="Edelson, Richard" sort="Edelson, Richard" uniqKey="Edelson R" first="Richard" last="Edelson">Richard Edelson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3B161DD9E3C101839CC7890B482E4C7F4373F573</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1111/j.1749-6632.2001.tb03715.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-CWWW2JZD-R/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001B52</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B52</idno><idno type="wicri:Area/Istex/Curation">001B52</idno><idno type="wicri:Area/Istex/Checkpoint">000E21</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000E21</idno><idno type="wicri:doubleKey">0077-8923:2001:Berger C:the:clonotypic:t</idno><idno type="wicri:Area/Main/Merge">003537</idno><idno type="wicri:Area/Main/Curation">003499</idno><idno type="wicri:Area/Main/Exploration">003499</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">The Clonotypic T Cell Receptor Is a Source of Tumor‐associated Antigens in Cutaneous T Cell Lymphoma</title><author><name sortKey="Berger, Carole L" sort="Berger, Carole L" uniqKey="Berger C" first="Carole L." last="Berger">Carole L. Berger</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Yale University, School of Medicine, New Haven, Connecticut 06520</wicri:regionArea><wicri:noRegion>Connecticut 06520</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Longley, Jack" sort="Longley, Jack" uniqKey="Longley J" first="Jack" last="Longley">Jack Longley</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Columbia University, College of Physicians & Surgeons, New York, New York 10032</wicri:regionArea><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hanlon, Douglas" sort="Hanlon, Douglas" uniqKey="Hanlon D" first="Douglas" last="Hanlon">Douglas Hanlon</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Yale University, School of Medicine, New Haven, Connecticut 06520</wicri:regionArea><wicri:noRegion>Connecticut 06520</wicri:noRegion></affiliation></author><author><name sortKey="Girardi, Michael" sort="Girardi, Michael" uniqKey="Girardi M" first="Michael" last="Girardi">Michael Girardi</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Yale University, School of Medicine, New Haven, Connecticut 06520</wicri:regionArea><wicri:noRegion>Connecticut 06520</wicri:noRegion></affiliation></author><author><name sortKey="Edelson, Richard" sort="Edelson, Richard" uniqKey="Edelson R" first="Richard" last="Edelson">Richard Edelson</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Yale University, School of Medicine, New Haven, Connecticut 06520</wicri:regionArea><wicri:noRegion>Connecticut 06520</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of the New York Academy of Sciences</title><title level="j" type="alt">ANNALS OF NEW YORK ACADEMY SCIENCES</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><biblScope unit="vol">941</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="106">106</biblScope><biblScope unit="page" to="122">122</biblScope><biblScope unit="page-count">17</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2001-09">2001-09</date></imprint><idno type="ISSN">0077-8923</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: To develop cancer vaccines for the treatment of cutaneous T cell lymphoma (CTCL), immunogenic peptides were identified by two approaches. First, through the use of “reverse immunology” the peptide sequence of the idiotypic region of the β chain of the T cell receptor (TCR) was determined and a series of overlapping peptides synthesized and tested for CD8 T cell recognition. In two patients, the idiotypic CDR3 region provided immunogenic epitopes that were recognized in a class I‐restricted fashion by autologous CD8 T cell lines. In a second strategy, peptides were isolated directly from class I MHC molecules on the CTCL surface and sequenced. A peptide with partial homology to sequences contained in the conserved variable portion of the clonotypic TCR β chain was recognized as immunogenic by autologous CD8 T cells. Therefore, both approaches demonstrated that the clonotypic TCR in CTCL is a source of immunogenic tumor epitopes. To confirm that recognition of TCR‐derived sequences provides immunoprotection against tumor growth, a murine model of T cell lymphoma was studied. The immunogenicity of a thymoma, which lacks cell surface TCR expression, was enhanced by transfection of the β chain of the TCR. The studies reviewed in this paper demonstrate that the TCR can serve as one source for immunogenic tumor peptides in T cell lymphoma in vitro and in vivo. Presentation of TCR epitopes on dendritic cells that express high levels of MHC, costimulatory, and adhesion molecules may provide an effective means for immunization against T cell malignancy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Berger, Carole L" sort="Berger, Carole L" uniqKey="Berger C" first="Carole L." last="Berger">Carole L. Berger</name></noRegion><name sortKey="Berger, Carole L" sort="Berger, Carole L" uniqKey="Berger C" first="Carole L." last="Berger">Carole L. Berger</name><name sortKey="Edelson, Richard" sort="Edelson, Richard" uniqKey="Edelson R" first="Richard" last="Edelson">Richard Edelson</name><name sortKey="Girardi, Michael" sort="Girardi, Michael" uniqKey="Girardi M" first="Michael" last="Girardi">Michael Girardi</name><name sortKey="Hanlon, Douglas" sort="Hanlon, Douglas" uniqKey="Hanlon D" first="Douglas" last="Hanlon">Douglas Hanlon</name><name sortKey="Longley, Jack" sort="Longley, Jack" uniqKey="Longley J" first="Jack" last="Longley">Jack Longley</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003499 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003499 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:3B161DD9E3C101839CC7890B482E4C7F4373F573
|texte= The Clonotypic T Cell Receptor Is a Source of Tumor‐associated Antigens in Cutaneous T Cell Lymphoma
}}
| This area was generated with Dilib version V0.6.33. |  |